Developmental regulation of immune system gene rearrangement

被引：33

作者：

Cedar, H ^{[1
]}

Bergman, Y

机构：

[1] Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Cellular Biochem, IL-91120 Jerusalem, Israel

[2] Hebrew Univ Jerusalem, Hadassah Med Sch, Hubert H Humphrey Ctr Expt Med & Canc Res, IL-91120 Jerusalem, Israel

来源：

CURRENT OPINION IN IMMUNOLOGY | 1999年 / 11卷 / 01期

基金：

美国国家卫生研究院; 以色列科学基金会;

关键词：

D O I：

10.1016/S0952-7915(99)80012-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Rearrangement of antigen receptors in the immune system is mediated through the action of complex enhancers which function in both a developmentally stage-specific and a cell-type-specific manner to demethylate DNA, open chromatin structure and tether the recombination machinery to one preferred allele at each locus.

引用

页码：64 / 69

页数：6

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