Dragon ERE Finder version 2:: a tool for accurate detection and analysis of estrogen response elements in vertebrate genomes

被引：104

作者：

Bajic, VB ^{[1
]}

Tan, SL

Chong, A

Tang, S

Ström, A

Gustafsson, JÅ

Lin, CY

Liu, ET

机构：

[1] Inst Infocomm Res, Knowledge Extract Lab, Singapore 119613, Singapore

[2] Karolinska Inst, Novum, Ctr Biotechnol, S-14157 Huddinge, Sweden

[3] Karolinska Inst, Novum, Dept Med Nutr, S-14157 Huddinge, Sweden

[4] Genome Inst Singapore, Singapore 117528, Singapore

来源：

NUCLEIC ACIDS RESEARCH | 2003年 / 31卷 / 13期

关键词：

D O I：

10.1093/nar/gkg517

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We present a unique program for identification of estrogen response elements (EREs) in genomic DNA and related analyses. The detection algorithm was tested on several large datasets and makes one prediction in 13 300 nt while achieving a sensitivity of 83%. Users can further investigate selected regions around the identified ERE patterns for transcription factor binding sites based on the TRANSFAC database. It is also possible to search for candidate human genes with a match for the identified EREs and their flanking regions within EPD annotated promoters. Additionally, users can search among the extended promoter regions of similar to11 000 human genes for those that have a high degree of similarity to the identified ERE patterns. Dragon ERE Finder version 2 is freely available for academic and non-profit users (http://sdmc.lit.org.sg/ERE-V2/index).

引用

页码：3605 / 3607

页数：3

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