cDNA cloning and transcript distribution of two novel members of the neuroparsin family in the desert locust, Schistocerca gregaria

被引：38

作者：

Claeys, I ^{[1
]}

Simonet, G ^{[1
]}

Van Loy, T ^{[1
]}

De Loof, A ^{[1
]}

Vanden Broeck, J ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Lab Dev Physiol & Mol Biol, Inst Zool, Dept Anim Physiol & Neurobiol, B-3000 Leuven, Belgium

来源：

INSECT MOLECULAR BIOLOGY | 2003年 / 12卷 / 05期

关键词：

hormone; insect; insulin; peptide; reproduction;

D O I：

10.1046/j.1365-2583.2003.00431.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study describes the identification and distribution of two novel neuroparsin precursor transcripts (Scg-NPP3/Scg-NPP4) in the desert locust, Schistocerca gregaria. Unlike Scg-NPP1 and Scg-NPP2, both transcripts were not only detected in the brain, but also in various other tissues, such as fat body, ventral nerve cord, testis and male accessory glands. Northern analysis showed that the levels of these transcripts are regulated during larval development, as well as during moulting and reproductive cycles. A significant increase in both mRNAs was observed during the period that just precedes the initial sexual activity of adult females and males. In silico analysis of sequence databases revealed the existence of several other neuroparsin-like peptides in a variety of arthropod species, including crustaceans and chelicerates. Neuroparsins also display similarities with vertebrate IGFBP.

引用

页码：473 / 481

页数：9

共 29 条

[1] Expression patterns of insulin-like growth factor-binding proteins 1, 2, 3, 5, and 6 in the mid-cycle monkey ovary [J].