The immune system in atherosclerosis

被引：1769

作者：

Hansson, Goran K. ^{[1
]}

Hermansson, Andreas ^{[1
]}

机构：

[1] Karolinska Inst, Karolinska Univ Hosp Solna, Ctr Mol Med, Dept Med, Stockholm, Sweden

来源：

NATURE IMMUNOLOGY | 2011年 / 12卷 / 03期

基金：

瑞典研究理事会;

关键词：

LOW-DENSITY-LIPOPROTEIN; REGULATORY T-CELLS; ALDEHYDE-MODIFIED PEPTIDE; RHEUMATOID-ARTHRITIS; APOLIPOPROTEIN B-100; INTERFERON-GAMMA; OXIDIZED LDL; AGGRAVATE ATHEROSCLEROSIS; ENHANCES ATHEROSCLEROSIS; REDUCED ATHEROSCLEROSIS;

D O I：

10.1038/ni.2001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cardiovascular disease, a leading cause of mortality worldwide, is caused mainly by atherosclerosis, a chronic inflammatory disease of blood vessels. Lesions of atherosclerosis contain macrophages, T cells and other cells of the immune response, together with cholesterol that infiltrates from the blood. Targeted deletion of genes encoding costimulatory factors and proinflammatory cytokines results in less disease in mouse models, whereas interference with regulatory immunity accelerates it. Innate as well as adaptive immune responses have been identified in atherosclerosis, with components of cholesterol-carrying low-density lipoprotein triggering inflammation, T cell activation and antibody production during the course of disease. Studies are now under way to develop new therapies based on these concepts of the involvement of the immune system in atherosclerosis.

引用

页码：204 / 212

页数：9

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