The role of anorexigenic and orexigenic neuropeptides and peripheral signals on quartiles of weight loss in obese adolescents

被引：28

作者：

Oyama, Lila Missae ^{[1
,2
]}

Oller do Nascimento, Claudia Maria ^{[2
,4
]}

Carnier, June ^{[2
]}

de Piano, Aline ^{[2
]}

Tock, Lian ^{[2
]}

Sanches, Priscila de Lima ^{[2
]}

Correa Gomes, Fabiola Alvise ^{[2
]}

Tufik, Sergio ^{[3
]}

de Mello, Marco Tulio ^{[2
,3
]}

Damaso, Ana R. ^{[1
,2
]}

机构：

[1] Univ Fed Sao Paulo Unifesp, Dept Biosci, BR-04020060 Sao Paulo, Brazil

[2] Univ Fed Sao Paulo Unifesp, Post Grad Program Nutr, BR-04020060 Sao Paulo, Brazil

[3] Univ Fed Sao Paulo Unifesp, Dept Psychobiol, BR-04020060 Sao Paulo, Brazil

[4] Univ Fed Sao Paulo Unifesp, Dept Physiol, BR-04020060 Sao Paulo, Brazil

来源：

NEUROPEPTIDES | 2010年 / 44卷 / 06期

基金：

巴西圣保罗研究基金会;

关键词：

Adipokines; Obesity; Energy regulation; Adolescents; Visceral fat; Therapy; MELANOCYTE-STIMULATING HORMONE; FOOD-INTAKE; BODY-COMPOSITION; PLASMA GHRELIN; ENERGY-INTAKE; VISCERAL FAT; LEPTIN; CHILDREN; INSULIN; ADIPOKINES;

D O I：

10.1016/j.npep.2010.07.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Obesity is characterized as an inflammatory state associated with a modification in the pattern of adipokine secretion The present study aimed to assess the role of anorexigenic and orexigenic neuropeptides and peripheral signals in obese adolescents submitted to 1 year of weight loss interdisciplinary therapy and grouped according to quartiles of weight loss A total of 111 post-puberty adolescents with a BMI >95th percentile were included Glycemia and lipid profiles were analyzed Insulin resistance was estimated by HOMA-IR. Cytokine concentrations were measured by ELISA. The results are presented according to quartiles of weight loss 1st (<2 5 kg) = low 2nd (2 5-8 kg) = low to moderate 3rd (8-14 kg) = moderate and 4th (>14 kg) = massive The most important finding was that the NPY concentration Increased significantly only in the first phase of weight loss Moreover alpha-MSH variation was an independent factor in explaining the NPY changes during the intervention confirming the role of the alpha-MSH concentration in the peripheral control of energy balance in obese adolescents Indeed BMI reduction was correlated with increased alpha-MSH (p < 0 05) Massive weight loss promoted a significant increase in alpha-MSH concentration and hyperleptinemia was reduced after intervention All together our findings which contribute to our understanding of how orexigenic and anorexigenic systems are regulated by weight loss will provide insight into the pathogenesis and treatment of obesity and other metabolic diseases especially in obese adolescents (C) 2010 Elsevier Ltd All rights reserved

引用

页码：467 / 474

页数：8

共 42 条

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