Spermine and thermine conjugates of cholic acid condense DNA, but lithocholic acid polyamine conjugates do so more efficiently

被引：25

作者：

Geall, AJ ^{[1
]}

Al-Hadithi, D ^{[1
]}

Blagbrough, IS ^{[1
]}

机构：

[1] Univ Bath, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, England

来源：

CHEMICAL COMMUNICATIONS | 1998年 / 18期

关键词：

D O I：

10.1039/a804924f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Polyamine amides have been prepared from cholic and lithocholic acid by acylation of tri-Boc protected spermine and thermine and their binding affinities for calf thymus DNA were determined using an ethidium bromide fluorescence quenching assay; these polyamine amides are models for lipoplex formation with respect to gene delivery (lipofection), a key first step in gene therapy.

引用

页码：2035 / 2036

页数：2

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