Novel data point to a broader mechanism of action of oxidized ATP:: the P2X7 receptor is not the only target

被引：56

作者：

Di Virgilio, F ^{[1
]}

机构：

[1] Univ Ferrara, Dept Expt & Diagnost Med, Sect Gen Pathol, I-44100 Ferrara, Italy

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2003年 / 140卷 / 03期

关键词：

P2X(7) receptor; extracellular ATP; inflammation; Schiff-base; danger signals;

D O I：

10.1038/sj.bjp.0705469

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Oxidized ATP (oATP) is a Schiff-base-forming reagent that has been used for some years as an antagonist at the P2X(7) receptor (P2X(7)R). Preincubation of mononuclear phagocytes with this inhibitor leads to attenuation of several proinflammatory responses triggered by extracellular ATP as well as a few non-nucleotide agonists. Novel data show that oATP reduces NFkappaB activation and IL-8 release in cells lacking P2X(7)R, thus suggesting that some anti-inflammatory effects of oATP may not be due to blockade of the P2X(7)R. This effect of oATP resembles the action of other natural or synthetic Schiff-base-forming reagents with immunomodulatory activity.

引用

收藏

页码：441 / 443

页数：3

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