A programmable one-pot oligosaccharide synthesis for diversifying the sugar domains of natural products: A case study of vancomycin

被引：80

作者：

Ritter, TK

Mong, KKT

Liu, HT

Nakatani, T

Wong, CH

机构：

[1] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 38期

关键词：

antibiotics; carbohydrates; glycosylation; oligosaccharides; vancomycin;

D O I：

10.1002/anie.200351534

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The notoriously difficult glycosylation of vancomycin was tackled in a one-pot procedure. A number of oligosaccharides were synthesized and attached to the vancomycin aglycon to create a library of derivatives (see formula) to probe the effect of glycosylation on the antibiotic activity.

引用

收藏

页码：4657 / 4660

页数：4

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