Association of methylenetetrahydrofolate reductase gene polymorphism with carotid atherosclerosis depending on smoking status in a Japanese general population

被引:69
作者
Inamoto, N
Katsuya, T
Kokubo, Y
Mannami, T
Asai, T
Baba, S
Ogata, J
Tomoike, H
Ogihara, T
机构
[1] Osaka Univ, Grad Sch Med, Dept Geriatr Med, Suita, Osaka 5650871, Japan
[2] Natl Cardiovasc Ctr, Dept Prevent Cardiol, Osaka, Japan
关键词
amine oxidoreductases; blood pressure; carotid arteries; Japan; risk factors;
D O I
10.1161/01.STR.0000075769.09092.82
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background and Purpose-The association of the methylenetetrahydrofolate reductase gene (MTHFR) with carotid atherosclerosis remains inconsistent. This may be due to small sample size and inappropriate analysis. We investigated the association of C677T/MTHFR with blood pressure and carotid atherosclerosis in a Japanese general population. Methods-Subjects (30 to 89 years of age; 1693 women, 1554 men) who gave informed consent were randomly selected from a general population in Suita, Japan. MTHFR genotypes were determined by TaqMan polymerase chain reaction. Carotid atherosclerosis was evaluated by high-resolution ultrasonography with atherosclerotic indexes of intimal-medial thickness (IMT), maximum IMT in the common carotid artery (CCA), plaque score, and stenosis (>50%). Results-Age-adjusted diastolic blood pressure was significantly higher in women with the TT genotype than in those with the CC genotype. In a recessive model (CC + CT versus TT), all adjusted odds ratios for hypertension and >50% stenosis in women were 1.42 and 3.42 (95% confidence intervals, 1.01 to 1.99 and 1.23 to 9.53), respectively. In women, maximum IMT in CCA for smokers with the TT genotype was significantly higher than for smokers with the CC genotype and nonsmokers with the TT genotype (P<0.05). Conclusions-Our study suggests that the MTHFR TT genotype is a risk factor for hypertension and carotid stenosis in women. Significant interactions between C677T/MTHFR and smoking on maximum IMT in CCA were observed in women but not in men. Smoking cessation for subjects with the TT genotype is important in the prevention of cerebrovascular disease.
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收藏
页码:1628 / 1633
页数:6
相关论文
共 37 条
[21]   Methylenetetrahydrofolate reductase gene polymorphism and ischemic stroke in Japanese [J].
Morita, H ;
Kurihara, H ;
Tsubaki, S ;
Sugiyama, T ;
Hamada, C ;
Kurihara, Y ;
Shindo, T ;
Oh-Hashi, Y ;
Kitamura, K ;
Yazaki, Y .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1998, 18 (09) :1465-1469
[22]   Common mutation in methylenetetrahydrofolate reductase. Correlation with homocysteine and other risk factors for vascular disease [J].
Motti, C ;
Gnasso, A ;
Bernardini, S ;
Massoud, R ;
Pastore, A ;
Rampa, P ;
Federici, G ;
Cortese, C .
ATHEROSCLEROSIS, 1998, 139 (02) :377-383
[23]   TOTAL PLASMA HOMOCYSTEINE AND CARDIOVASCULAR RISK PROFILE - THE HORDALAND HOMOCYSTEINE STUDY [J].
NYGARD, O ;
VOLLSET, SE ;
REFSUM, H ;
STENSVOLD, I ;
TVERDAL, A ;
NORDREHAUG, JE ;
UELAND, PM ;
KVALE, G .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1995, 274 (19) :1526-1533
[24]   Plasma homocysteine, methylenetetrahydrofolate reductase mutation and carotid damage in elderly healthy women [J].
Passaro, A ;
Vanini, A ;
Calzoni, F ;
Alberti, L ;
Zamboni, PF ;
Fellin, R ;
Solini, A .
ATHEROSCLEROSIS, 2001, 157 (01) :175-180
[25]   A PROSPECTIVE-STUDY OF CEREBRAL-ARTERY ATHEROSCLEROSIS [J].
REED, DM ;
RESCH, JA ;
HAYASHI, T ;
MACLEAN, C ;
YANO, K .
STROKE, 1988, 19 (07) :820-825
[26]   Homocysteine and cardiovascular disease [J].
Refsum, H ;
Ueland, PM ;
Nygård, O ;
Vollset, SE .
ANNUAL REVIEW OF MEDICINE, 1998, 49 :31-62
[27]   THE PATHOGENESIS OF ATHEROSCLEROSIS - A PERSPECTIVE FOR THE 1990S [J].
ROSS, R .
NATURE, 1993, 362 (6423) :801-809
[28]   Single and combined prothrombotic factors in patients with idiopathic venous thromboembolism - Prevalence and risk assessment [J].
Salomon, O ;
Steinberg, DM ;
Zivelin, A ;
Gitel, S ;
Dardik, R ;
Rosenberg, N ;
Berliner, S ;
Inbal, A ;
Many, A ;
Lubetsky, A ;
Varon, D ;
Martinowitz, U ;
Seligsohn, U .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1999, 19 (03) :511-518
[29]  
Schwartz SM, 1997, CIRCULATION, V96, P412
[30]   VITAMIN STATUS AND INTAKE AS PRIMARY DETERMINANTS OF HOMOCYSTEINEMIA IN AN ELDERLY POPULATION [J].
SELHUB, J ;
JACQUES, PF ;
WILSON, PWF ;
RUSH, D ;
ROSENBERG, IH .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1993, 270 (22) :2693-2698