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Human and mouse proteases:: A comparative genomic approach

被引：702
作者：
Puente, XS
Sánchez, LM
Overall, CM
López-Otín, C
机构：
[1] Univ Oviedo, Dept Bioquim & Biol Mol, Fac Med, Univ Oncol, E-33006 Oviedo, Spain
[2] Univ British Columbia, Dept Biochem & Mol Biol, Vancouver, BC V6T 1Z3, Canada
[3] Univ British Columbia, Dept Oral Biol, Vancouver, BC V6T 1Z3, Canada
[4] Univ British Columbia, Dept Med Sci, CIHR Grp Matrix Dynam, Vancouver, BC V6T 1Z3, Canada
来源：
NATURE REVIEWS GENETICS | 2003年 / 4卷 / 07期
关键词：
D O I：
10.1038/nrg1111
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The availability of the human and mouse genome sequences has allowed the identification and comparison of their respective degradomes - the complete repertoire of proteases that are produced by these organisms. Because of the essential roles of proteolytic enzymes in the control of cell behaviour, survival and death, degradome analysis provides a useful framework for the global exploration of these protease-mediated functions in normal and pathological conditions.
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收藏
页码：544 / 558
页数：15
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