A prepro-orexin gene polymorphism is associated with narcolepsy

被引：49

作者：

Gencik, M

Dahmen, N

Wieczorek, S

Kasten, M

Bierbrauer, J

Anghelescu, I

Szegedi, A

Saecker, AMM

Epplen, JT

机构：

[1] Ruhr Univ Bochum, St Josef Hosp, Dept Human Mol Genet, D-44780 Bochum, Germany

[2] Ruhr Univ Bochum, St Josef Hosp, Neurol Klin, D-44780 Bochum, Germany

[3] Univ Mainz, Psychiat Klin, D-6500 Mainz, Germany

来源：

NEUROLOGY | 2001年 / 56卷 / 01期

关键词：

D O I：

10.1212/WNL.56.1.115

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The orexin (hypocretin) neurotransmitter system was recently shown to be directly involved in the pathogenesis of narcolepsy in two animal models. Furthermore, decreased levels of orexin A in the CSF were shown in narcoleptic patients. To define any genetic contribution of orexin to the etiology of narcolepsy, the authors screened the entire prepro-orexin in gene for mutations or polymorphisms in 133 patients suffering from narcolepsy. They report an association of a rare polymorphism in the prepro-orexin gene with narcolepsy in a cohort of 178 patients.

引用

页码：115 / 117

页数：3

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