Development and performance analysis of PCL/silica nanocomposites for bone regeneration

被引：29

作者：

Calandrelli, Luigi ^{[1
]}

Annunziata, Marco ^{[3
]}

Della Ragione, Fulvio ^{[2
]}

Laurienzo, Paola ^{[1
]}

Malinconico, Mario ^{[1
]}

Oliva, Adriana ^{[2
]}

机构：

[1] CNR, Inst Polymers Chem & Technol, I-80078 Naples, Italy

[2] Univ Naples 2, Fac Med, Dept Biochem & Biophys, Naples, Italy

[3] Univ Naples 2, Dept Odontostomatol, Orthodont & Surg Disciplines, Naples, Italy

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2010年 / 21卷 / 11期

关键词：

MESENCHYMAL STEM-CELLS; NANOPHASE CERAMICS; BIOMEDICAL APPLICATIONS; MECHANICAL-PROPERTIES; SILICA NANOPARTICLES; OSTEOBLAST ADHESION; DIFFERENTIATE; GROWTH;

D O I：

10.1007/s10856-010-4156-8

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

In the present article, several developments of biocomposites containing silica nanoparticles intended for bone regeneration are reported. Nanocomposites of poly(epsilon-caprolactone) (PCL) and silica, in which either the silica nanoparticles or the PCL have been modified in order to improve interfacial adhesion through chemical graft between the phases are hereafter described. The composites are characterized with respect to their chemical-physical and mechanical properties. Their biocompatibility and capacity to induce the osteoblastic phenotype in human bone marrow mesenchymal stem cells have been assessed.

引用

页码：2923 / 2936

页数：14

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