Microdialysis for in vivo pharmacokinetic/pharmacodynamic characterization of anti-infective drugs

被引:66
作者
Brunner, M
Derendorf, H
Müller, M
机构
[1] Med Univ Vienna, Div Clin Pharmacokinet, Dept Clin Pharmacol, A-1090 Vienna, Austria
[2] Univ Florida, Dept Pharm Practice, Gainesville, FL 32610 USA
[3] Univ Florida, Dept Pharmaceut, Gainesville, FL 32610 USA
基金
奥地利科学基金会;
关键词
D O I
10.1016/j.coph.2005.04.010
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Inadequate tissue penetration of antibiotics can lead to therapeutic failure and bacterial resistance. Pharmacokinetic evaluation of antibiotics should therefore be based on tissue rather than serum concentrations. Over several years, tissue concentration data obtained by methods such as tissue biopsies have flawed the correct interpretation of antibiotic tissue distribution. Microdialysis - a semi-invasive catheter-based sampling technique - has been employed for the in vivo measurement of antibiotic tissue pharmacokinetics. Owing to selective access to the target site for most anti-infective drugs, microdialysis satisfies regulatory requirements for pharmacokinetic distribution studies and might become a reference technique for tissue distribution studies in the near future. Furthermore, microdialysis might contribute to the definition of meaningful surrogate markers for antibiotic efficiency during drug development.
引用
收藏
页码:495 / 499
页数:5
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