Molecular Pathways Underlying Cardiac Remodeling During Pathophysiological Stimulation

被引:475
作者
Kehat, Izhak [1 ]
Molkentin, Jeffery D. [1 ,2 ]
机构
[1] Univ Cincinnati, Cincinnati Childrens Hosp, Dept Pediat, Cincinnati, OH 45229 USA
[2] Howard Hughes Med Inst, Med Ctr, Cincinnati, OH 45229 USA
基金
美国国家卫生研究院;
关键词
ATRIAL-NATRIURETIC-PEPTIDE; ENDOTHELIAL GROWTH-FACTOR; HEART-FAILURE; MYOCARDIAL-INFARCTION; PRESSURE-OVERLOAD; TARGETED DELETION; IN-VIVO; VENTRICULAR ENLARGEMENT; HYPERTROPHIC RESPONSE; CLINICAL-IMPLICATIONS;
D O I
10.1161/CIRCULATIONAHA.110.942268
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页码:2727 / 2735
页数:9
相关论文
共 81 条
[1]   CaMKII and a failing strategy for growth in heart [J].
Anderson, Mark E. .
JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (05) :1082-1085
[2]  
ANVERSA P, 1991, AM J CARDIOL, V68, pD7
[3]   The δ isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload [J].
Backs, Johannes ;
Backs, Thea ;
Neef, Stefan ;
Kreusser, Michael M. ;
Lehmann, Lorenz H. ;
Patrick, David M. ;
Grueter, Chad E. ;
Qi, Xiaoxia ;
Richardson, James A. ;
Hill, Joseph A. ;
Katus, Hugo A. ;
Bassel-Duby, Rhonda ;
Maier, Lars S. ;
Olson, Eric N. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (07) :2342-2347
[4]   Molecular regulation of cardiac hypertrophy [J].
Barry, Sean P. ;
Davidson, Sean M. ;
Townsend, Paul A. .
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2008, 40 (10) :2023-2039
[5]   Pathological and physiological hypertrophies are regulated by distinct gene programs [J].
Beisvag, Vidar ;
Kemi, Ole Johan ;
Arbo, Ingerid ;
Loennechen, Jan Pal ;
Wisloff, Ulrik ;
Langaas, Mette ;
Sandvik, Arne Kristian ;
Ellingsen, Oyvind .
EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION, 2009, 16 (06) :690-697
[6]   Putting the brakes on cardiac hypertrophy - Exploiting the NO-cGMP counter-regulatory system [J].
Booz, GW .
HYPERTENSION, 2005, 45 (03) :341-346
[7]   NFATc2 is a necessary mediator of calcineurin-dependent cardiac hypertrophy and heart failure [J].
Bourajjaj, Meriem ;
Armand, Anne-Sophie ;
Martins, Paula A. da Costa ;
Weijts, Bart ;
van der Nagel, Roel ;
Heeneman, Sylvia ;
Wehrens, Xander H. ;
De Windt, Leon J. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (32) :22295-22303
[8]  
BRAUNWALD E, 1991, AM J CARDIOL, V68, pD1
[9]   PKC-α regulates cardiac contractility and propensity toward heart failure [J].
Braz, JC ;
Gregory, K ;
Pathak, A ;
Zhao, W ;
Sahin, B ;
Klevitsky, R ;
Kimball, TF ;
Lorenz, JN ;
Nairn, AC ;
Liggett, SB ;
Bodi, I ;
Wang, S ;
Schwartz, A ;
Lakatta, EG ;
DePaoli-Roach, AA ;
Robbins, J ;
Hewett, TE ;
Bibb, JA ;
Westfall, MV ;
Kranias, EG ;
Molkentin, JD .
NATURE MEDICINE, 2004, 10 (03) :248-254
[10]   Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NEAT signaling [J].
Braz, JC ;
Bueno, OF ;
Liang, QR ;
Wilkins, BJ ;
Dai, YS ;
Parsons, S ;
Braunwart, J ;
Glascock, BJ ;
Klevitsky, R ;
Kimball, TF ;
Hewett, TE ;
Molkentin, JD .
JOURNAL OF CLINICAL INVESTIGATION, 2003, 111 (10) :1475-1486