An Ex(o)citing Machinery for Invasive Tumor Growth

被引：83

作者：

Hendrix, An ^{[1
]}

Westbroek, Wendy ^{[2
]}

Bracke, Marc ^{[1
]}

De Wever, Olivier ^{[1
]}

机构：

[1] Ghent Univ Hosp, Lab Expt Canc Res, Dept Radiat Oncol & Expt Canc Res, B-9000 Ghent, Belgium

[2] NHGRI, Med Genet Branch, Bethesda, MD 20892 USA

来源：

CANCER RESEARCH | 2010年 / 70卷 / 23期

关键词：

CANCER-CELL INVASION; EXOCYTOSIS; SECRETION; GTPASES; TRAFFICKING; HSP90-ALPHA; EXPRESSION; PROTEOMICS; EXOSOMES; PATHWAY;

D O I：

10.1158/0008-5472.CAN-10-3248

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer cells communicate with the environment through delivery of surface proteins, release of soluble factors (growth factors and cytokines), and sophisticated nanovehicles (exosomes) for establishment of invasive tumor growth. This communication occurs in part through constitutive exocytosis, regulated exocytosis, or release of intraluminal vesicles, and is modulated by small Rab GTPases, the master regulators of vesicle traffic. We studied Rab GTPases implicated in regulated exocytosis and showed a unique role for Rab27B in invasive tumor growth. Emerging evidence indicates that various exocytic routes are implemented by cancer cells to relay crucial information for fostering growth, migration, and matrix degradation. Cancer Res; 70(23); 9533-7. (C) 2010 AACR.

引用

页码：9533 / 9537

页数：5

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