Identification and characterization of satellite III subfamilies to the acrocentric chromosomes

被引：25

作者：

Bandyopadhyay, R

McQuillan, C

Page, SL

Choo, KHA

Shaffer, LG ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

[2] Royal Childrens Hosp, Murdoch Childrens Res Inst, Murdoch, WA, Australia

来源：

CHROMOSOME RESEARCH | 2001年 / 9卷 / 03期

基金：

美国国家卫生研究院;

关键词：

acrocentric chromosome; chromosome evolution; fluorescence in-situ hybridization; repetitive DNA; satellite DNA; Robertsonian translocations;

D O I：

10.1023/A:1016648404388

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The centromeres and the short arms of the five pairs of acrocentric chromosomes in humans are composed of tandemly ordered repetitive DNA. Previous studies have suggested that the exchanges between acrocentric chromosomes have resulted in concerted evolution of different DNA sequences in their short arms. The acrocentric chromosomes are clinically relevant since they are involved in Robertsonian translocation formation and non-disjunction resulting in aneuploidy. Here we have identified seven new satellite III repetitive DNA subfamilies, determined their nucleotide sequences and established their chromosomal distributions on the short arms of the acrocentric chromosomes. Knowledge of these related sequences may help to elucidate the molecular basis of Robertsonian translocation formation.

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页码：223 / 233

页数：11

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