Angiogenesis and bone repair

被引：619

作者：

Carano, RAD

Filvaroff, EH

机构：

[1] Genentech Inc, Dept Physiol, San Francisco, CA 94080 USA

[2] Genentech Inc, Dept Mol Oncol, San Francisco, CA 94080 USA

来源：

DRUG DISCOVERY TODAY | 2003年 / 8卷 / 21期

关键词：

D O I：

10.1016/S1359-6446(03)02866-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The intimate connection, both physical and biochemical, between blood vessels and bone cells has long been recognized. Genetic, biochemical, and pharmacological studies have identified and characterized factors involved in the conversation between endothelial cells (EC) and osteoblasts (OB) during both bone formation and repair. The long-awaited FDA approval of two growth factors, BMP-2 and OP-1, with angiogenic and osteogenic activity confirms the importance of these two processes in human skeletal healing. In this review, the role of osteogenic factors in the adaptive response and interactive function of OB and EC during the multi-step process of bone repair will be discussed.

引用

收藏

页码：980 / 989

页数：10

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