Synthesis and biological activity of analogues of ptilomycalin A

被引：24

作者：

Black, GP

Coles, SJ

Hizi, A

Howard-Jones, AG

Hursthouse, MB

McGown, AT

Loya, S

Moore, CG

Murphy, PJ ^{[1
]}

Smith, NK

Walshe, NDA

机构：

[1] Univ Wales, Dept Chem, Bangor LL57 2UW, Gwynedd, Wales

[2] Pfizer Ltd, Cent Res, Sandwich CT13 9NJ, Kent, England

[3] Tel Aviv Univ, Sackler Sch Med, Dept Cell Biol & Histol, Tel Aviv, Israel

[4] Christie Hosp NHS Trust, Paterson Inst Canc Res, Christie CRC Res Ctr, Manchester M20 4BX, Lancs, England

[5] Univ Southampton, Dept Chem, Southampton SO17 1BJ, Hants, England

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 19期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/S0040-4039(01)00400-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Benzo-fused model compounds 21a and 21b, resembling in structure the marine metabolite ptilomycalin A, were prepared and were shown to display significant activity against a series of cancer cell lines and to also possess a significant activity against the DNA polymerase activity of the reverse transcriptase of human immunodeficiency virus type 1 (HIV-1 RT). (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：3377 / 3381

页数：5

共 15 条

[1] SALINE HYDRIDES AND SUPERBASES IN ORGANIC REACTIONS .9. ACETYLENE ZIPPER - EXCEPTIONALLY FACILE CONTRATHERMODYNAMIC MULTIPOSITIONAL ISOMERIZATION OF ALKYNES WITH POTASSIUM 3-AMINOPROPYLAMIDE [J].