The guanidine metabolites of Ptilocaulis spiculifer and related compounds; isolation and synthesis

被引：247

作者：

Heys, L ^{[1
]}

Moore, CG ^{[1
]}

Murphy, PJ ^{[1
]}

机构：

[1] Univ Wales, Dept Chem, Bangor LL57 2UW, Gwynedd, Wales

来源：

CHEMICAL SOCIETY REVIEWS | 2000年 / 29卷 / 01期

关键词：

D O I：

10.1039/a903712h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Marine natural products possessing guanidine functionalities display a considerable array of biological activity and not surprisingly have attracted considerable synthetic interest. This review discusses the isolation of several guanidine containing metabolites, primarily from the sponge Ptilocaulis spiculifer , but also from other marine organisms. It also explores the synthetic methodologies adopted for their preparation and speculates on the structural similarity of the metabolite ptilomycalin A to abiotic guanidine based anionic receptor molecules.

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页码：57 / 67

页数：11

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