An inflammatory triangle in psoriasis: TNF, type I IFNs and IL-17

被引：198

作者：

Grine, Lynda ^{[1
,2
]}

Dejager, Lien ^{[1
,2
]}

Libert, Claude ^{[1
,2
]}

Vandenbroucke, Roosmarijn E. ^{[1
,2
]}

机构：

[1] VIB, Inflammat Res Ctr, Ghent, Belgium

[2] Univ Ghent, Dept Biomed Mol Biol, B-9000 Ghent, Belgium

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2015年 / 26卷 / 01期

关键词：

Psoriasis; TNF; Tumor necrosis factor; Type I interferons; IL-17/IL-23; NECROSIS-FACTOR-ALPHA; INTERFERON-ALPHA; SKIN INFLAMMATION; MULTIPLE-SCLEROSIS; DENDRITIC CELLS; GENE POLYMORPHISMS; PLAQUE-FORMATION; CROHNS-DISEASE; MESSENGER-RNA; LESIONAL SKIN;

D O I：

10.1016/j.cytogfr.2014.10.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Psoriasis is a skin disease where various cytokines play a detrimental role, yet our understanding of the disease is still limited. TNF is a validated drug target in psoriasis and other autoimmune diseases, but its use is associated with side effects. Some paradoxical side effects of anti-TNF treatment are supposedly associated with type I IFNs, which are also implicated in the pathogenesis of psoriasis. Recently, the IL-23/IL-17 axis has been associated with psoriasis as well, and new drugs targeting this axis have already been developed. Findings suggest that these cytokines are interwoven. We discuss recent findings reinforcing the role of TNF, Type I IFNs and IL-17 in the pathogenesis of psoriasis and the apparent inflammatory interplay between these three cytoldnes. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：25 / 33

页数：9

共 99 条

[1]

Induction and exacerbation of psoriasis with Interferon-alpha therapy for hepatitis C: A review and analysis of 36 cases [J].

Afshar, M. ;

Martinez, A. D. ;

Gallo, R. L. ;

Hata, T. R. .

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2013, 27 (06) :771-778

[2]

Interleukin-17 is produced by both Th1 and Th2 lymphocytes, and modulates interferon-γ- and interleukin-4-induced activation of human keratinocytes [J].

Albanesi, C ;

Scarponi, CS ;

Cavani, A ;

Federici, M ;

Nasorri, F ;

Girolomoni, G .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2000, 115 (01) :81-87

[3]

Community differentiation of the cutaneous microbiota in psoriasis [J].

Alekseyenko, Alexander V. ;

Perez-Perez, Guillermo I. ;

De Souza, Aieska ;

Strober, Bruce ;

Gao, Zhan ;

Bihan, Monika ;

Li, Kelvin ;

Methe, Barbara A. ;

Blaser, Martin J. .

MICROBIOME, 2013, 1

[4]

Alterations in serum MMP-8, MMP-9, IL-12p40 and IL-23 in multiple sclerosis patients treated with interferon-β1b [J].

Alexander, J. S. ;

Harris, M. K. ;

Wells, S. R. ;

Mills, G. ;

Chalamidas, K. ;

Ganta, V. C. ;

McGee, J. ;

Jennings, M. H. ;

Gonzalez-Toledo, E. ;

Minagar, A. .

MULTIPLE SCLEROSIS JOURNAL, 2010, 16 (07) :801-809

[5]

Almoallim H, 2012, OPEN RHEUMATOL J, V6, P315, DOI [DOI 10.2174/1874312901206010315, 10.2174/1874312901206010315]

[6]

Endothelial cell-derived microparticles induce plasmacytoid dendritic cell maturation: potential implications in inflammatory diseases [J].

Angelot, Fanny ;

Seilles, Estelle ;

Biichle, Sabeha ;

Berda, Yael ;

Gaugler, Beatrice ;

Plumas, Joel ;

Chaperot, Laurence ;

Dignat-George, Francoise ;

Tiberghien, Pierre ;

Saas, Philippe ;

Garnache-Ottou, Francine .

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2009, 94 (11) :1502-1512

[7]

Antoni C, 2002, CLIN EXP RHEUMATOL, V20, pS152

[8]

Functional caspase-1 is required for langerhans cell migration and optimal contact sensitization in mice [J].

Antonopoulos, H ;

Cumberbatch, M ;

Dearman, RJ ;

Daniel, RJ ;

Kimber, I ;

Groves, RW .

JOURNAL OF IMMUNOLOGY, 2001, 166 (06) :3672-3677

[9]

T helper type 1 and 17 cells determine efficacy of interferon-β in multiple sclerosis and experimental encephalomyelitis [J].

Axtell, Robert C. ;

de Jong, Brigit A. ;

Boniface, Katia ;

van der Voort, Laura F. ;

Bhat, Roopa ;

De Sarno, Patrizia ;

Naves, Rodrigo ;

Han, May ;

Zhong, Franklin ;

Castellanos, Jim G. ;

Mair, Robert ;

Christakos, Athena ;

Kolkowitz, Ilan ;

Katz, Liat ;

Killestein, Joep ;

Polman, Chris H. ;

Malefyt, Rene de Waal ;

Steinman, Lawrence ;

Raman, Chander .

NATURE MEDICINE, 2010, 16 (04) :406-U21

[10]

Anti-tumour necrosis factor-α therapy in heart failure:: Future directions [J].

Balakumar, Pitchai ;

Singh, Manjeet .

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2006, 99 (06) :391-397

← 1 2 3 4 5 6 7 8 9 10 →