Central administration of phosphatidylserine attenuates isolation stress-induced behavior in chicks

被引:56
作者
Koutoku, T
Takahashi, H
Tomonaga, S
Oikawa, D
Saito, S
Tachibana, T
Han, L
Hayamizu, K
Denbow, DM
Furuse, M [1 ]
机构
[1] Kyushu Univ, Grad Sch Bioresource & Bioenvironm Sci, Lab Adv Anim & Marine Bioresource, Fukuoka 8128581, Japan
[2] FANCL Corp, Cent Lab, Totsuka Ku, Yokohama, Kanagawa 2440806, Japan
[3] Virginia Polytech Inst & State Univ, Dept Anim & Poultry Sci, Blacksburg, VA 24061 USA
基金
日本学术振兴会;
关键词
phosphatidylserine; L-serine; stress; acetylcholine receptor; chick;
D O I
10.1016/j.neuint.2005.03.006
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The present study investigated whether centrally administered phosphatidylserine (PS) could modify the behavior of chicks under isolation-induced stress. Isolation stress-induced vocalization and spontaneous activity for 10 min, which were attenuated by intracerebroventricular (i.c.v.) injection of PS. The effect of PS was compared with other phospholipids or L-serine, a constituent of PS. Phosphatidylcholine (PC) had no effect on these behavior, but phosphatidylethanolamine (PE) significantly increased vocalizations and spontaneous activity compared with PS. L-Serine similarly decreased isolation-induced vocalizations and spontaneous activity. To clarify the mechanism by which central PS attenuates isolation-induced stress behavior, the contribution of the acetylcholine (ACh) receptor (AChR) was also investigated. PS was co-injected i.c.v. with the muscarinic AChR (M-AM) antagonist scopolamine or the nicotinic AChR (N-AChR) antagonist hexamethonium. The suppression of vocalizations and spontaneous activity by PS was partially attenuated by scopolamine, but not hexamethonium. These findings indicate that isolation-induced stress behavior are attenuated by PS, acting partially through the M-AChR. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码:183 / 189
页数:7
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