Halogenation strategies in natural product biosynthesis

被引：275

作者：

Neumann, Christopher S. ^{[1
]}

Fujimori, Danica Galonic ^{[1
]}

Walsh, Christopher T. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

来源：

CHEMISTRY & BIOLOGY | 2008年 / 15卷 / 02期

关键词：

D O I：

10.1016/j.chembiol.2008.01.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Halogenation is a frequent modification of secondary metabolites and can play a significant role in establishing the bioactivity of a compound. Enzymatic halogenation through oxidative mechanisms is the most common route to these metabolites, though direct halogenation via halide anion incorporation is also known to proceed through both enzymatic and nonenzymatic pathways. In this article, we review the current state of knowledge regarding the mechanisms of these transformations, highlight applications of this knowledge, and propose future opportunities and challenges for the field.

引用

页码：99 / 109

页数：11

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