Primary immunodeficiency diseases: an experimental model for molecular medicine

被引：71

作者：

Fischer, A ^{[1
]}

机构：

[1] Hop Necker Enfants Malad, INSERM, U429, F-75015 Paris, France

来源：

LANCET | 2001年 / 357卷 / 9271期

关键词：

D O I：

10.1016/S0140-6736(00)04959-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Primary immunodeficiency diseases represent a vast array of inherited disorders of the immune system. Major advances in the understanding of genetic basis and molecular mechanisms have occurred within the past 10 years, as a result of the tools of modern genetics. About three quarters of 100 primary immunodeficiency diseases can now be reliably diagnosed with molecular probes. In many cases, gene identification has enabled significant insight into the physiopathology of the related conditions. Therapeutic progress based on protein engineering and possibly gene therapy will also ensue.

引用

页码：1863 / 1869

页数：7

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