Triggers, targets and treatments for thrombosis

被引：944

作者：

Mackman, Nigel ^{[1
]}

机构：

[1] Univ N Carolina, Div Hematol Oncol, Dept Med, Chapel Hill, NC 27599 USA

来源：

NATURE | 2008年 / 451卷 / 7181期

关键词：

D O I：

10.1038/nature06797

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Thrombosis-localized clotting of the blood-can occur in the arterial or the venous circulation and has a major medical impact. Acute arterial thrombosis is the proximal cause of most cases of myocardial infarction ( heart attack) and of about 80% of strokes, collectively the most common cause of death in the developed world. Venous thromboembolism is the third leading cause of cardiovascular-associated death. The pathogenic changes that occur in the blood vessel wall and in the blood itself resulting in thrombosis are not fully understood. Understanding these processes is crucial for developing safer and more effective antithrombotic drugs.

引用

页码：914 / 918

页数：5

共 59 条

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