The role of calcium metabolism in human red blood cell ageing: A proposal

被引：45

作者：

Romero, PJ ^{[1
]}

Romero, EA ^{[1
]}

机构：

[1] Cent Univ Venezuela, Fac Sci, Inst Expt Biol, Lab Membrane Physiol, Caracas 1041A, Venezuela

来源：

BLOOD CELLS MOLECULES AND DISEASES | 1999年 / 25卷 / 01期

关键词：

erythrocytes; ageing; intracellular Ca; K(Ca)channel; Ca pump proteolysis;

D O I：

10.1006/bcmd.1999.0222

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The mechanisms of recognition, trapping and destruction of senescent human erythrocytes are not completely understood. Here we discuss some evidences supporting the idea that red cell ageing is closely related to a progressive increase in intracellular ionic Ca. This in turn, is the determining factor of a series of events such as Ca pump proteolysis and opening of the Ca-dependent K channel, that finally lead to the removal of old cells by macrophages at spleen level, (C) 1998 Academic Press.

引用

页码：9 / 19

页数：11

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