Topical chemotherapy for experimental African trypanosomiasis with cerebral involvement: The use of melarsoprol combined with the 5-nitroimidazole, megazol

被引:17
作者
Jennings, FW
Chauviere, G
Viode, C
Murray, M
机构
[1] UNIV GLASGOW,DEPT VET MED,GLASGOW G61 1QH,LANARK,SCOTLAND
[2] UNIV TOULOUSE 3,GRP CHIM ORGAN BIOL,CNRS,URA 470,F-31062 TOULOUSE,FRANCE
关键词
5-nitroimidazoles; megazol; melarsoprol; CNS-trypanosomiasis;
D O I
10.1046/j.1365-3156.1996.d01-46.x
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Megazol, one of a number of related 5-nitroimidazoles, can be dissolved in dimethylsulphoxide and the solution can be converted into a gel by the addition of hydroxypropylcellulose which facilitates the ease and accuracy of administration. This megazol gel, when used in combination with melarsoprol (3.6%) in propylene glycol gel, will cure experimental CNS-trypanosomiasis in mice. A single application of 0.1 ml of melarsoprol (3.6%) gel plus 0.1 ml of either 8 or 16 mg/ml megazol gel successfully treated experimental CNS-trypanosomiasis while two consecutive days' treatment with 0.05 ml melarsoprol and 0.1 ml of 16 or 32 mg/ml megazol gels also produced satisfactory cures.
引用
收藏
页码:363 / 366
页数:4
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