SUCCESSFUL TREATMENT OF EXPERIMENTAL MURINE TRYPANOSOMA-BRUCEI INFECTION WITH TOPICAL MELARSOPROL GEL

Melarsoprol gel applied topically (0.1 mL for at least 2 d) can cure late-stage Trypanosoma brucei brucei and T, b. rhodesiense infections in mice. The best regimen was 3 applications at approximately 0, 6 and 24 h. The melarsoprol gel retained its activity at room temperature for at least 63 d. There was only minimal skin irritation and no sign of toxicity.