On-off transport through a thermoresponsive hydrogel composite membrane

被引：69

作者：

Li, SK ^{[1
]}

D'Emanuele, A ^{[1
]}

机构：

[1] Univ Manchester, Sch Pharm & Pharmaceut Sci, Manchester M13 9PL, Lancs, England

来源：

JOURNAL OF CONTROLLED RELEASE | 2001年 / 75卷 / 1-2期

基金：

英国生物技术与生命科学研究理事会;

关键词：

temperature-modulated drug delivery systems thermoresponsive hydrogel; N-isopropylacrylamide; thermoresponsive membrane; cryo-scanning electron microscopy;

D O I：

10.1016/S0168-3659(01)00365-0

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel thermoresponsive composite membrane is described through which the permeation of molecules is dependent on the temperature of the milieu. The thermoresponsive composite membranes utilise a thermosensitive crosslinked polymeric hydrogel, which possesses a volume phase transition temperature (VPTT). The hydrogel was polymerised in situ within the pores of a sintered glass filter, through which significant permeation of molecules only occurred at temperatures above the VPTT of the hydrogel. It was found that the permeation of molecules through the thermoresponsive composite membranes could be modulated by changing the environmental temperature. (C) 2001 Elsevier Science BY All rights reserved.

引用

页码：55 / 67

页数：13