Clinical and genetic characterization of severe influenza B-associated diseases during an outbreak in Taiwan

被引：42

作者：

Li, Wen-Chen ^{[1
,2
,8
]}

Shih, Shin-Ru ^{[5
,6
,8
]}

Huang, Yhu-Chering ^{[1
,3
,8
]}

Chen, Guang-Wu ^{[7
,8
]}

Chang, Shih-Cheng ^{[5
,6
,8
]}

Hsiao, Mei-Jen ^{[4
]}

Tsao, Kuo-Chien ^{[4
,5
,6
,8
]}

Lin, Tzou-Yien ^{[1
,3
,8
]}

机构：

[1] Chang Gung Childrens Hosp, Div Pediat Infect Dis, Tao Yuan, Taiwan

[2] Chang Gung Univ, Grad Inst Clin Med Sci, Tao Yuan, Taiwan

[3] Chang Gung Univ, Coll Med, Sch Med, Tao Yuan, Taiwan

[4] Chang Gung Mem Hosp, Dept Clin Pathol, Clin Virol Lab, Tao Yuan, Taiwan

[5] Chang Gung Univ, Dept Med Biotechnol, Tao Yuan, Taiwan

[6] Chang Gung Univ, Lab Serv, Tao Yuan, Taiwan

[7] Chang Gung Univ, Dept Comp Sci & Informat Engn, Tao Yuan, Taiwan

[8] Chang Gung Univ, Res Ctr Emerging Viral Infect, Tao Yuan, Taiwan

来源：

JOURNAL OF CLINICAL VIROLOGY | 2008年 / 42卷 / 01期

关键词：

influenza B virus; encephalitis/encephalopathy; influenza-associated myositis; acute respiratory distress syndrome; genetic evolution;

D O I：

10.1016/j.jcv.2007.11.026

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Background Mismatches between circulating and vaccine strains of influenza virus had been observed in Taiwan. A comprehensive clinical and genetic analysis of influenza B viruses-associated important diseases was lacking. Objectives: Clinical and phylogenetic analysis of influenza B viruses during an outbreak in Taiwan. Study designs: Clinical manifestations of hospitalized, culture-confirmed patients were analyzed from July 2004 to June 2005. Partial genome sequence analysis of hemagglutinin (HA), neuraminidase (NA), and nonstructural (NS) genes were performed in 54 influenza B isolates during the study period, and nine srandomly chosen isolates during 2000 and 2003. Results: Three specific diseases were found in these patients, including 13 of encephalitis/encephalopathy, 28 of influenza-associated myositis (IAM), and one of acute respiratory distress syndrome (ARDS). Three phylogenetic groups were identified, including reassortant strains-group 1 (Victoria lineage of HA, Yamagata lineage of NA, clade A of NS), group 2 (Yamagata lineage of HA, Yamagata lineage of NA, clade A of NS), and group 3 (Yamagata lineage of HA, Yamagata lineage of NA, clade B of NS). Conclusions: Severe influenza B-associated disease in children was not rare and might be fatal. We offered the evidence of co-circulation of the two HA lineages in the same outbreak. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：45 / 51

页数：7

共 22 条

[21] INFLUENZA-B VIRUS EVOLUTION - CO-CIRCULATING LINEAGES AND COMPARISON OF EVOLUTIONARY PATTERN WITH THOSE OF INFLUENZA-A AND INFLUENZA-C VIRUSES [J].