8-methyl-pyridoxatin:: A novel N-hydroxy pyridone from fungus OS-F61800 that induces erythropoietin in human cells

被引：21

作者：

Cai, P

Smith, D

Cunningham, B

Brown-Shimer, S

Katz, B

Pearce, C

Venables, D

Houck, D

机构：

[1] MYCOsearch, Durham, NC 27707 USA

[2] OSI Pharmaceut, Uniondale, NY 11553 USA

[3] Univ Utah, Dept Med Chem, Salt Lake City, UT 84112 USA

[4] Oncogene Sci Diagnost, Cambridge, MA 02142 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 02期

关键词：

D O I：

10.1021/np980450t

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

In the course of screening for small-molecule modulators of erythropoietin gene expression, a novel N-hydroxy pyridone was isolated from a culture of OS-F61800. Its structure was elucidated by extensive H-1 and C-13 NMR spectroscopic and chemical studies. This compound induced erythropoietin gene expression fivefold at a concentration of 0.3 mu M, which is about threefold greater potency than our previously identified erythropoietin inducers.

引用

页码：397 / 399

页数：3

共 8 条

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