Epolones: Novel sesquiterpene-tropolones from fungus OS-F69284 that induce erythropoietin in human cells

被引：54

作者：

Cai, P

Smith, D

Cunningham, B

Brown-Shimer, S

Katz, B

Pearce, C

Venables, D

Houck, D

机构：

[1] MYCOsearch, Durham, NC 27707 USA

[2] Univ Utah, Dept Med Chem, Salt Lake City, UT 84112 USA

[3] OSI Pharmaceut, Uniondale, NY 11553 USA

[4] Oncogene Sci Diagnost, Cambridge, MA 02142 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 06期

关键词：

D O I：

10.1021/np9800506

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

In the course of our screening for small molecule modulators of erythropoietin gene expression, two novel sesquiterpene tropolones and pycnidone were isolated from a culture of OS-F69284 (ATCC 74390). Their structures were elucidated by extensive H-1 and C-13 NMR spectroscopic studies and chemical reactions. These compounds induced erythropoietin gene expression 5-fold at a concentration of 1-1.6 mu M.

引用

页码：791 / 795

页数：5

共 8 条

[1]

Breitmaier E., 1987, CARBON 13 NMR SPECTR, P115

[2] Destruxin-A4 chlorohydrin, a novel destruxin from fungus OS-F68576: Isolation, structure determination, and biological activity as an inducer of erythropoietin [J].

Cai, P ;

Smith, D ;

Katz, BL ;

Pearce, C ;

Venables, D ;

Houck, D .

JOURNAL OF NATURAL PRODUCTS, 1998, 61 (02) :290-293

[3] ISOLATION AND STRUCTURE DETERMINATION OF PYCNIDIONE, A NOVEL BISTROPOLONE STROMELYSIN INHIBITOR FROM A PHOMA SP [J].

HARRIS, GH ;

HOOGSTEEN, K ;

SILVERMAN, KC ;

RAGHOOBAR, SL ;

BILLS, GF ;

LINGHAM, RB ;

SMITH, JL ;

DOUGHERTY, HW ;

CASCALES, C ;

PELAEZ, F .

TETRAHEDRON, 1993, 49 (11) :2139-2144

[4]

HEGUY A, 1995, GENE EXPRESSION, V4, P337

[5]

KRANTZ SB, 1991, BLOOD, V77, P419

[6] EUPENIFELDIN, A NOVEL CYTOTOXIC BISTROPOLONE FROM EUPENICILLIUM-BREFELDIANUM [J].

MAYERL, F ;

GAO, Q ;

HUANG, S ;

KLOHR, SE ;

MATSON, JA ;

GUSTAVSON, DR ;

PIRNIK, DM ;

BERRY, RL ;

FAIRCHILD, C ;

ROSE, WC .

JOURNAL OF ANTIBIOTICS, 1993, 46 (07) :1082-1088

[7] BMY-28438 (3,7-DIHYDROXYTROPOLONE), A NEW ANTITUMOR ANTIBIOTIC ACTIVE AGAINST B-16 MELANOMA .1. PRODUCTION, ISOLATION, STRUCTURE AND BIOLOGICAL-ACTIVITY [J].

SUGAWARA, K ;

OHBAYASHI, M ;

SHIMIZU, K ;

HATORI, M ;

KAMEI, H ;

KONISHI, M ;

OKI, T ;

KAWAGUCHI, H .

JOURNAL OF ANTIBIOTICS, 1988, 41 (07) :862-868

[8]

WEEGEN H, 1990, J ORG CHEM, V55, P5107

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