Atopic dermatitis: a candidate for disease-modifying strategy

被引：85

作者：

Bieber, T. ^{[1
]}

Cork, M. ^{[2
]}

Reitamo, S. ^{[3
]}

机构：

[1] Univ Bonn, Dept Dermatol & Allergy, D-53105 Bonn, Germany

[2] Univ Sheffield, Dept Infect & Immun, Acad Unit Dermatol Res, Sheffield, S Yorkshire, England

[3] Univ Helsinki, Dept Dermatol, Skin & Allergy Hosp, Helsinki, Finland

来源：

ALLERGY | 2012年 / 67卷 / 08期

关键词：

asthma; atopic dermatitis; atopic march; disease modification; MACROPHAGE-DERIVED CHEMOKINE; 0.1-PERCENT TACROLIMUS OINTMENT; OF-FUNCTION MUTATIONS; TOPICAL TACROLIMUS; FOLLOW-UP; STAPHYLOCOCCAL COLONIZATION; FILAGGRIN MUTATIONS; CHILDREN; ASTHMA; SEVERITY;

D O I：

10.1111/j.1398-9995.2012.02845.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100108 [医学免疫学];

摘要：

The concept of disease modification has been introduced to define the therapeutic strategies aimed to break, stop, or reverse the natural course of a chronic invalidating disease. This strategy is tightly related to the biomarker-based stratification of affected patients using genetic and other biological markers. With regard to the progress in understanding the genetic background of atopic dermatitis (AD), its natural history and its pivotal role in the emergence of allergic asthma, the time is mature to foster the research field of biomarkers in AD and to consider the elaboration of disease-modifying strategies in the management of AD with the goal to stop or even reverse the atopic march.

引用

页码：969 / 975

页数：7

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