Nucleophile-catalyzed asymmetric acylations of silyl ketene imines: Application to the enantioselective synthesis of verapamil

被引：110

作者：

Mermerian, AH ^{[1
]}

Fu, GC ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 06期

关键词：

acylation; asymmetric synthesis; cyanides; homogeneous catalysis; total synthesis;

D O I：

10.1002/anie.200461886

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

All-carbon quaternary stereocenters are generated with good enantioselectivity through a nucleophile-catalyzed acylation reaction of silyl ketene imines (see scheme, TBS = tert-butyldimethylsilyl). The method is applied to the first catalytic asymmetric synthesis of the drug verapamil.

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收藏

页码：949 / 952

页数：4

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