Cortactin phosphorylation as a switch for actin cytoskeletal network and cell dynamics control

被引：109

作者：

Lua, BL ^{[1
]}

Low, BC ^{[1
]}

机构：

[1] Natl Univ Singapore, Dept Biol Sci, Cell Signaling & Dev Biol Lab, Singapore 117543, Singapore

来源：

FEBS LETTERS | 2005年 / 579卷 / 03期

关键词：

cortactin; Src; Erk; kinase; phosphorylation; actin cytoskeleton;

D O I：

10.1016/j.febslet.2004.12.055

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cortactin is an important molecular scaffold for actin assembly and organization. Novel mechanistic functions of cortactin have emerged with more interacting partners identified, revealing its multifaceted roles in regulating actin cytoskeletal networks that are necessary for endocytosis, cell migration and invasion, adhesion, synaptic organization and cell morphogenesis. These processes are mediated by its multi-domains binding to F-actin and Arp2/3 complex and various SH3 targets. Furthermore, its role in actin remodeling is subjected to regulation by tyrosine and serine/threonine kinases. Elucidating the mechanisms underlying cortactin phosphorylation and its functional consequences would provide new insights to various aspects of cell dynamics control. (C) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：577 / 585

页数：9

共 80 条

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