Iridium-Catalyzed Asymmetric Allylic Amination with Polar Amines: Access to Building Blocks with Lead-Like Molecular Properties

被引：36

作者：

Tosatti, Paolo ^{[1
]}

Horn, Joachim ^{[1
]}

Campbell, Amanda J. ^{[2
]}

House, David ^{[2
]}

Nelson, Adam ^{[1
]}

Marsden, Stephen P. ^{[1
]}

机构：

[1] Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England

[2] GlaxoSmithKline, Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2010年 / 352卷 / 18期

基金：

英国工程与自然科学研究理事会;

关键词：

allylic compounds; allylic substitution; asymmetric catalysis; iridium; lead-like compounds; COMPLEXES-RESTING STATES; ENANTIOSELECTIVE ALLYLATION; PHOSPHORAMIDITE LIGANDS; SUBSTITUTIONS; HETEROCYCLES; CYCLIZATION; DISCOVERY; SELECTION; ALCOHOLS; AMMONIA;

D O I：

10.1002/adsc.201000721

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The combination of an air-stable iridium catalyst and the dipolar aprotic solvent dimethyl sulfoxide (DMSO) allowed, for the first time, the systematic exploitation of highly polar, functionalized amines in asymmetric allylic substitutions: low molecular weight, sp(3)-rich chiral building blocks were obtained with physicochemical properties that will be valuable in the synthesis of lead-like small molecules.

引用

页码：3153 / 3157

页数：5

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