NMDA receptor-mediated oscillatory activity in the neonatal rat spinal cord is serotonin dependent

被引：63

作者：

MacLean, JN ^{[1
]}

Cowley, KC ^{[1
]}

Schmidt, BJ ^{[1
]}

机构：

[1] Univ Manitoba, Dept Physiol, Winnipeg, MB R3E 0W3, Canada

来源：

JOURNAL OF NEUROPHYSIOLOGY | 1998年 / 79卷 / 05期

关键词：

D O I：

10.1152/jn.1998.79.5.2804

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of serotonin (5-HT) receptor blockade on rhythmic network activity and on N-methyl-D-aspartate (NMDA) receptor-induced membrane voltage oscillations was examined using an in vitro neonatal rat spinal cord preparation. Pharmacologically induced rhythmic hindlimb activity, monitored via flexor and extensor electroneurograms or ventral root recordings, was abolished by 5-HT receptor antagonists. Intrinsic motoneuronal voltage oscillations, induced by NMDA in the presence of tetrodotoxin (TTX), either were abolished completely or transformed to longlasting voltage shifts by 5-HT receptor antagonists. Conversely, 5-HT application facilitated the expression of NMDA-receptor-mediated rhythmic voltage oscillations. The results suggest that an interplay between 5-HT and NMDA receptor actions may be critical for the production of rhythmic motor behavior in the mammalian spinal cord, both at the network and single cell level.

引用

页码：2804 / 2808

页数：5

共 40 条

[21] DYNAMIC NEUROMODULATION OF SYNAPTIC STRENGTH INTRINSIC TO A CENTRAL PATTERN GENERATOR CIRCUIT [J].

KATZ, PS ;

GETTING, PA ;

FROST, WN .

NATURE, 1994, 367 (6465) :729-731

[22]

MACLEAN JN, 1995, NEURON NETWORKS MOT

[23]

MACLEAN JN, 1996, SOC NEUR ABSTR, V22

[24] SEROTONIN SUPPRESSES N-METHYL-D-ASPARTATE RESPONSES IN ACUTELY ISOLATED SPINAL DORSAL HORN NEURONS OF THE RAT [J].

MURASE, K ;

RANDIC, M ;

SHIRASAKI, T ;

NAKAGAWA, T ;

AKAIKE, N .

BRAIN RESEARCH, 1990, 525 (01) :84-91

[25] THE MODULATION OF EXCITATORY AMINO-ACID RESPONSES BY SEROTONIN IN THE CAT NEOCORTEX INVITRO [J].

NEDERGAARD, S ;

ENGBERG, I ;

FLATMAN, JA .

CELLULAR AND MOLECULAR NEUROBIOLOGY, 1987, 7 (04) :367-379

[26] SEROTONIN FACILITATES NMDA RESPONSES OF CAT NEOCORTICAL NEURONS [J].

NEDERGAARD, S ;

ENGBERG, I ;

FLATMAN, JA .

ACTA PHYSIOLOGICA SCANDINAVICA, 1986, 128 (02) :323-325

[27] THE MORPHOLOGY AND DISTRIBUTION OF RAT SEROTONINERGIC INTRASPINAL NEURONS - AN IMMUNOHISTOCHEMICAL STUDY [J].

NEWTON, BW ;

HAMILL, RW .

BRAIN RESEARCH BULLETIN, 1988, 20 (03) :349-360

[28] SEROTONIN-LIKE, SUBSTANCE P-LIKE AND GLUTAMATE ASPARTATE-LIKE IMMUNOREACTIVITIES IN MEDULLO-SPINAL PATHWAYS OF RAT AND PRIMATE [J].

NICHOLAS, AP ;

PIERIBONE, VA ;

ARVIDSSON, U ;

HOKFELT, T .

NEUROSCIENCE, 1992, 48 (03) :545-559

[29] ACTIVATION OF 5-HT2 RECEPTORS FACILITATES DEPOLARIZATION OF NEOCORTICAL NEURONS BY N-METHYL-D-ASPARTATE [J].

RAHMAN, S ;

NEUMAN, RS .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1993, 231 (03) :347-354

[30] THE EFFECTS OF SEROTONIN ON N-METHYL-D-ASPARTATE AND SYNAPTICALLY EVOKED DEPOLARIZATIONS IN RAT NEOCORTICAL NEURONS [J].

REYNOLDS, JN ;

BASKYS, A ;

CARLEN, PL .

BRAIN RESEARCH, 1988, 456 (02) :286-292

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