Cutaneous reactivity of the hands in nickel-sensitive patients with hand eczema

被引：18

作者：

Banfield, CC ^{[1
]}

Basketter, DA

Powell, SM

机构：

[1] Stoke Mandeville Hosp, Aylesbury HP21 8AL, Bucks, England

[2] Unilever Res, Sharnbrook MK44 1LQ, Beds, England

[3] Churchill Hosp, Oxford OX3 7LJ, England

来源：

CONTACT DERMATITIS | 1998年 / 38卷 / 06期

关键词：

nickel; hand eczema; allergic contact dermatitis; serial dilution patch testing; cutaneous reactivity; elicitation threshold; exposure studies;

D O I：

10.1111/j.1600-0536.1998.tb05765.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

This study compares the cutaneous reactivity between the hand and the back for 7 female patients with active hand eczema, who were found to be nickel-sensitive on routine patch testing with the European standard series. Patients were patch tested to a dilution series of nickel sulfate on the back in order to determine the threshold concentration for elicitation of allergic contact dermatitis, and based upon this result a lower concentration of nickel was then used for patch tests on the hand. We found that in the majority of patients (6/7) the cutaneous responsiveness of the hand was not increased compared with that of the back. However, the hand of 1 patient was more sensitive to nickel and patch testing was accompanied with a flare of her eczema, which suggests that cutaneous hyperreactivity may be important in individual patients with hand eczema.

引用

页码：316 / 318

页数：3