Effect of Weight Loss, Diet, Exercise, and Bariatric Surgery on Nonalcoholic Fatty Liver Disease

被引：121

作者：

Hannah, William N., Jr. ^{[1
]}

Harrison, Stephen A. ^{[2
]}

机构：

[1] JBSA, Dept Med, San Antonio Mil Med Ctr, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA

[2] JBSA, Div Gastroenterol, Dept Med, San Antonio Mil Med Ctr, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA

来源：

CLINICS IN LIVER DISEASE | 2016年 / 20卷 / 02期

关键词：

Nonalcoholic fatty liver disease; Weight loss; Diet; Exercise; Bariatric surgery; LIFE-STYLE MODIFICATION; CARDIOVASCULAR-DISEASE; MEDICAL THERAPY; GASTRIC BYPASS; OBESE-PATIENTS; FRUCTOSE; STEATOHEPATITIS; RISK; CARBOHYDRATE; MANAGEMENT;

D O I：

10.1016/j.cld.2015.10.008

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome. NAFLD is the most common liver disease in developed countries. Weight reduction of 3% to 5% is associated with improved steatosis; reductions of 5% to 7% are necessary for decreased inflammation; with 7% to 10%, individuals may experience NAFLD/NASH remission and regression of fibrosis. No specific dietary intervention has proven beneficial beyond calorie restriction. Physical activity without weight loss seems to decrease hepatic steatosis. Bariatric surgery is associated with decreased cardiovascular risk and improved overall mortality in addition to reduction in hepatic steatosis, inflammation, and fibrosis.

引用

页码：339 / 350

页数：12

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