α-synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy

被引：523

作者：

Wakabayashi, K

Yoshimoto, M

Tsuji, S

Takahashi, H

机构：

[1] Niigata Univ, Brain Res Inst, Brain Dis Res Ctr, Niigata 9518585, Japan

[2] Taisho Pharmaceut Co Ltd, Med Res Labs, Mol Biol Lab, Ohmiya, Saitama 3300031, Japan

[3] Niigata Univ, Brain Res Inst, Dept Neurol, Niigata 9518585, Japan

[4] Niigata Univ, Brain Res Inst, Dept Pathol, Niigata 9518585, Japan

来源：

NEUROSCIENCE LETTERS | 1998年 / 249卷 / 2-3期

关键词：

alpha-synuclein; multiple system atrophy; glial cytoplasmic inclusion; oligodendrocyte; tubulin; neurodegeneration; immunohistochemistry;

D O I：

10.1016/S0304-3940(98)00407-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Lewy bodies in Parkinson's disease (PD) are strongly immunoreactive with antibodies against alpha-synuclein, which is mutated in some familial cases of the disease. We carried out immunohistochemical examinations of the brains of multiple system atrophy (MSA) patients using anti-alpha-synuclein antibodies. Strong a-synuclein immunoreactivity was found in glial cytoplasmic inclusions (GCIs), which are of oligodendroglial origin and occur exclusively in MSA. alpha-Synuclein-immunoreactive neuronal cytoplasmic inclusions (NCIs) were also found occasionally in the substantia nigra, pontine and inferior olivary nuclei, and dentate fascia. These findings indicate that alpha-synuclein is also a major component of GCIs and NCIs in MSA and strongly suggest that alpha-synuclein aggregation is a common process in certain neurodegenerative diseases, including PD and MSA. (C) 1998 Published by Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：180 / 182

页数：3

共 17 条

[1] IMMUNOHISTOCHEMICAL EXPRESSION OF MICROTUBULE-ASSOCIATED PROTEIN-5 (MAP5) IN GLIAL-CELLS IN MULTIPLE SYSTEM ATROPHY [J].