High-yielding microwave-assisted synthesis of triazole-linked glycodendrimers by copper-catalyzed [3+2] cycloaddition

被引：114

作者：

Joosten, JAF ^{[1
]}

Tholen, NTH ^{[1
]}

El Maate, FA ^{[1
]}

Brouwer, AJ ^{[1
]}

van Esse, GW ^{[1
]}

Rijkers, DTS ^{[1
]}

Liskamp, RMJ ^{[1
]}

Pieters, RJ ^{[1
]}

机构：

[1] Utrecht Inst Pharmaceut Sci, Dept Med Chem, NL-3508 TB Utrecht, Netherlands

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 2005卷 / 15期

关键词：

carbohydrates; glycosides; dendrimers; cycloaddition; microwave activation;

D O I：

10.1002/ejoc.200500216

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile and high-yielding synthesis of multivalent 1,4-disubstituted 1,2,3-triazole-linked glycodendrimers is described. Azido carbohydrates are linked by a Cu-I-catalyzed [3+2] cycloaddition reaction to dendritic acetylenes using microwave irradiation. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005).

引用

页码：3182 / 3185

页数：4