Fetal-maternal microchimerism: impact on hematopoietic stem cell transplantation

被引:37
作者
Ichinohe, T
Teshima, T
Matsuoka, K
Maruya, E
Saji, H
机构
[1] Kyoto Univ, Dept Hematol Oncol, Grad Sch Med, Sakyo Ku, Kyoto 6068507, Japan
[2] Kyushu Univ Hosp, Ctr Cellular & Mol Med, Higashi Ku, Fukuoka 8128582, Japan
[3] Okayama Univ, Grad Sch Med & Dent, Okayama 7008558, Japan
[4] NPO, HLA Lab, Sakyo Ku, Kyoto 6068396, Japan
关键词
D O I
10.1016/j.coi.2005.07.009
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Reciprocal cell traffic between mother and fetus during pregnancy gives rise to postpartum fetal-maternal lymphohematopoietic microchimerism, which is frequently detected in blood or tissue from healthy individuals. Although such microchimerism has been implicated in the pathogenesis of autoimmune diseases and tissue repair, recent clinical experiences have suggested the association of microchimerism with acquired immunologic hyporesponsiveness to non-inherited maternal HLA antigens (NIMAs) or inherited paternal HLAantigens (IPAs); T cell-replete HLA- haploidentical hematopoietic stem cell transplantation from a microchimeric IPA/NIMA-mismatched donor confers relatively lower incidence of severe graft-versus-host disease. The underlying mechanisms by which fetal-maternal microchimerism contributes to IPA/NIMA-specific tolerance are still elusive, although emerging experimental evidence suggests an involvement of the central deletion of IPA/NIMA-reactive T cells, the induction of peripheral regulatory T cells, and affinity-dependent modulation of NIMA-reactive B cells.
引用
收藏
页码:546 / 552
页数:7
相关论文
共 51 条
[1]   Regulatory T cells mediate maternal tolerance to the fetus [J].
Aluvihare, VR ;
Kallikourdis, M ;
Betz, AG .
NATURE IMMUNOLOGY, 2004, 5 (03) :266-271
[2]   Tolerance to noninherited maternal MHC antigens in mice [J].
Andrassy, J ;
Kusaka, S ;
Jankowska-Gan, E ;
Torrealba, JR ;
Haynes, LD ;
Marthaler, BR ;
Tam, RC ;
Illigens, BMW ;
Anosova, N ;
Benichou, G ;
Burlingham, WJ .
JOURNAL OF IMMUNOLOGY, 2003, 171 (10) :5554-5561
[3]   ACTIVELY ACQUIRED TOLERANCE OF FOREIGN CELLS [J].
BILLINGHAM, RE ;
BRENT, L ;
MEDAWAR, PB .
NATURE, 1953, 172 (4379) :603-606
[4]   The influence of immunosuppressive drugs on tolerance induction through bone marrow transplantation with costimulation blockade [J].
Blaha, P ;
Bigenzahn, S ;
Koporc, Z ;
Schmid, M ;
Langer, F ;
Selzer, E ;
Bergmeister, H ;
Wrba, F ;
Kurtz, J ;
Kiss, C ;
Roth, E ;
Muehlbacher, F ;
Sykes, M ;
Wekerle, T .
BLOOD, 2003, 101 (07) :2886-2893
[5]   The cellular immune response of children is specifically decreased against their parents but not vice versa, independent of pregnancy, age, or HLA or HY antigens [J].
Brune, T ;
Riepe, FG ;
Garritsen, H ;
Exeler, R ;
Louwen, F ;
Harms, E .
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2003, 49 (05) :255-260
[6]   MICROCHIMERISM LINKED TO CYTOTOXIC T-LYMPHOCYTE FUNCTIONAL UNRESPONSIVENESS (CLONAL ANERGY) IN A TOLERANT RENAL-TRANSPLANT RECIPIENT [J].
BURLINGHAM, WJ ;
GRAILER, AP ;
FECHNER, JH ;
KUSAKA, S ;
TRUCCO, M ;
KOCOVA, M ;
BELZER, FO ;
SOLLINGER, HW .
TRANSPLANTATION, 1995, 59 (08) :1147-1155
[7]   BREAST-FEEDING AND MATERNAL-DONOR RENAL-ALLOGRAFTS - POSSIBLY THE ORIGINAL DONOR-SPECIFIC TRANSFUSION [J].
CAMPBELL, DA ;
LORBER, MI ;
SWEETON, JC ;
TURCOTTE, JG ;
NIEDERHUBER, JE ;
BEER, AE .
TRANSPLANTATION, 1984, 37 (04) :340-344
[9]   CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation [J].
Edinger, M ;
Hoffmann, P ;
Ermann, J ;
Drago, K ;
Fathman, CG ;
Strober, S ;
Negrin, RS .
NATURE MEDICINE, 2003, 9 (09) :1144-1150
[10]  
Eto M, 1999, IMMUNOLOGY, V96, P440