Use of tigecycline for the treatment of prolonged bacteremia due to a multiresistant VIM-1 and SHV-12 β-lactamase-producing Klebsiella pneumoniae epidemic clone

被引：45

作者：

Cobo, Javier ^{[1
]}

Morosini, Maria-Isabel ^{[2
,3
]}

Pintado, Vicente ^{[1
]}

Tato, Marta ^{[2
]}

Samaranch, Noemi

Baquero, Fernando ^{[2
,3
]}

Canton, Rafael ^{[3
]}

机构：

[1] Hosp Univ Ramon & Cajal, Serv Enfermedades Infecc, Madrid 28034, Spain

[2] Hosp Univ Ramon & Cajal, Microbiol Serv, Madrid 28034, Spain

[3] CIBER ESP, Madrid 28034, Spain

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2008年 / 60卷 / 03期

关键词：

tigecycline; Bacteremia; K; pneumoniae; metallo-beta-lactamase;

D O I：

10.1016/j.diagmicrobio.2007.09.017

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We report the use of tigecycline, firstly with colistin and finally alone, in a patient with a persistent breakthrough bacteremia due to a Klebsiella pneumoniae isolate harboring a metallo-beta-lactamase (VIM-1) and an extended-spectrum beta-lactamase (SHV-12). Time-kill studies demonstrated that the combination of both compounds was synergistic along the first 12 h, suppressing the regrowth observed after 3 to 6 h when colistin was tested alone. (c) 2008 Elsevier Inc. All rights reserved.

引用

页码：319 / 322

页数：4

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