Significant drug interaction: Phenytoin toxicity due to erlotinib

被引：27

作者：

Grenader, Tal ^{[1
]}

Gipps, Maya ^{[1
]}

Shavit, Linda ^{[2
]}

Gabizon, Alberto ^{[1
]}

机构：

[1] Shaare Zedek Med Ctr, Dept Oncol, IL-91031 Jerusalem, Israel

[2] Shaare Zedek Med Ctr, Dept Med, IL-91031 Jerusalem, Israel

来源：

LUNG CANCER | 2007年 / 57卷 / 03期

关键词：

non-small cell lung cancer; erlotinib; phenytoin; drug interaction;

D O I：

10.1016/j.lungcan.2007.02.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Brain metastases are a frequent finding in patients with advanced non-small cell lung cancer and concomitant administration of antiepileptic and chemotherapeutic drugs or epidermal growth factor receptor (EGFR) inhibitor is necessary in many cases. Anticonvulsants have clinically significant interactions with other drugs used in brain tumor patients. We report a case in which a potential drug interaction resulted in elevated phenytoin levels after initiation of erlotinib therapy in a patient who was receiving phenytoin. (c) 2007 Elsevier Iretand Ltd. All rights reserved.

引用

页码：404 / 406

页数：3

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