Synthesis of a thioester linker precursor for a general preparation of peptide C-terminal thioacids

被引：13

作者：

Gaertner, H

Villain, M

Botti, P

Canne, L

机构：

[1] Geneprot, CH-1217 Meyrin 2, Switzerland

[2] Gryphon Therapeut, San Francisco, CA 94080 USA

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 10期

关键词：

thioacids; thioesters; C-terminal modified peptides;

D O I：

10.1016/j.tetlet.2003.12.160

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general procedure to prepare peptide thioacids by solid-phase peptide synthesis is presented. The method involves the synthesis of 4-[alpha-(S-acetyl)mercaptobenzyl]phenoxyacetic acid as general precursor. This reagent once attached to a solid support is derivatized with the Boc-amino acid of choice after deprotection of the thiol. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：2239 / 2241

页数：3

共 8 条

[1] A GENERAL-METHOD FOR THE SYNTHESIS OF THIOESTER RESIN LINKERS FOR USE IN THE SOLID-PHASE SYNTHESIS OF PEPTIDE-ALPHA-THIOACIDS [J].