共 77 条
Caspases: an ancient cellular sword of Damocles
被引:88
作者:

Boyce, M
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机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Degterev, A
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h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

Yuan, J
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h-index: 0
机构:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA
机构:
[1] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA
关键词:
invertebrate caspases;
ced-3;
C;
elegans;
Drosophila;
evolution;
D O I:
10.1038/sj.cdd.4401339
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Caspases are a family of cysteine proteases homologous to the Caenorhabditis elegans programmed cell death gene product CED-3. Caspases and their distant relatives, meta- and paracaspases, have been found in phylogenetically distant nonmetazoan groups, including plants, fungi and prokaryotes. This review summarizes the current information on the mechanisms and functions of non-mammalian caspases and their relatives in apoptotic and nonapoptotic processes, and explores the possible evolutionary origin of the caspase family.
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页码:29 / 37
页数:9
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