Caspases: an ancient cellular sword of Damocles

被引:88
作者
Boyce, M [1 ]
Degterev, A [1 ]
Yuan, J [1 ]
机构
[1] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA
关键词
invertebrate caspases; ced-3; C; elegans; Drosophila; evolution;
D O I
10.1038/sj.cdd.4401339
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Caspases are a family of cysteine proteases homologous to the Caenorhabditis elegans programmed cell death gene product CED-3. Caspases and their distant relatives, meta- and paracaspases, have been found in phylogenetically distant nonmetazoan groups, including plants, fungi and prokaryotes. This review summarizes the current information on the mechanisms and functions of non-mammalian caspases and their relatives in apoptotic and nonapoptotic processes, and explores the possible evolutionary origin of the caspase family.
引用
收藏
页码:29 / 37
页数:9
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