Caspases: an ancient cellular sword of Damocles

被引：88

作者：

Boyce, M ^{[1
]}

Degterev, A ^{[1
]}

Yuan, J ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

来源：

CELL DEATH AND DIFFERENTIATION | 2004年 / 11卷 / 01期

关键词：

invertebrate caspases; ced-3; C; elegans; Drosophila; evolution;

D O I：

10.1038/sj.cdd.4401339

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Caspases are a family of cysteine proteases homologous to the Caenorhabditis elegans programmed cell death gene product CED-3. Caspases and their distant relatives, meta- and paracaspases, have been found in phylogenetically distant nonmetazoan groups, including plants, fungi and prokaryotes. This review summarizes the current information on the mechanisms and functions of non-mammalian caspases and their relatives in apoptotic and nonapoptotic processes, and explores the possible evolutionary origin of the caspase family.

引用

页码：29 / 37

页数：9

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