Variations in the FTO gene are associated with severe obesity in the Japanese

被引：216

作者：

Hotta, Kikuko ^{[1
]}

Nakata, Yoshio ^{[2
]}

Matsuo, Tomoaki ^{[2
]}

Kamohara, Seika ^{[3
]}

Kotani, Kazuaki ^{[4
]}

Komatsu, Ryoya ^{[6
]}

Itoh, Naoto ^{[5
]}

Mineo, Ikuo ^{[7
]}

Wada, Jun ^{[8
]}

Masuzaki, Hiroaki ^{[9
]}

Yoneda, Masato ^{[10
]}

Nakajima, Atsushi ^{[10
]}

Miyazaki, Shigeru ^{[11
]}

Tokunaga, Katsuto ^{[12
]}

Kawamoto, Manabu ^{[13
]}

Funahashi, Tohru ^{[4
]}

Hamaguchi, Kazuyuki

Yamada, Kentaro

Hanafusa, Toshiaki

Oikawa, Shinichi

Yoshimatsu, Hironobu

Nakao, Kazuwa ^{[9
]}

Sakata, Toshiie

Matsuzawa, Yuji ^{[4
]}

Tanaka, Kiyoji ^{[2
]}

Kamatani, Naoyuki ^{[13
]}

Nakamura, Yusuke

机构：

[1] RIKEN, SNP Res Ctr, Lab Obes, Tsurumi Ku, Kanagawa 2300045, Japan

[2] Univ Tsukuba, Inst Hlth & Sport Sci, Ibaraki, Japan

[3] Tokyo Med Univ, Med & Hlth Sci Inst, Tokyo, Japan

[4] Osaka Univ, Grad Sch Med, Dept Metab Med, Osaka, Japan

[5] Toyonaka City Hosp, Osaka, Japan

[6] Rinku Gen Med Ctr, Osaka, Japan

[7] Otemae Hosp, Osaka, Japan

[8] Okayama Univ, Grad Sch Med & Dent, Dept Med & Clin Sci, Okayama 7008530, Japan

[9] Kyoto Univ, Grad Sch Med, Dept Med & Clin Sci, Kyoto, Japan

[10] Yokohama City Univ, Div Gastroenterol, Yokohama, Kanagawa 232, Japan

[11] Tokyo Postal Serv Agcy Hosp, Tokyo, Japan

[12] Itami City Hosp, Hyogo, Japan

[13] Tokyo Womens Med Univ, Inst Rheumatol, Tokyo, Japan

来源：

JOURNAL OF HUMAN GENETICS | 2008年 / 53卷 / 06期

基金：

英国科研创新办公室;

关键词：

fat-mass and obesity-associated gene; obesity; Japanese population; association; SNP;

D O I：

10.1007/s10038-008-0283-1

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Variations in the fat-mass and obesity-associated gene (FTO) are associated with the obesity phenotype in many Caucasian populations. This association with the obesity phenotype is not clear in the Japanese. To investigate the relationship between the FTO gene and obesity in the Japanese, we genotyped single nucleotide polymorphisms (SNPs) in the FTO genes from severely obese subjects [n = 927, body mass index (BMI) >= 30 kg/m(2)] and normal-weight control subjects (n = 1,527, BMI < 25 kg/m(2)). A case-control association analysis revealed that 15 SNPs, including rs9939609 and rs1121980, in a linkage disequilibrium (LD) block of approximately 50 kb demonstrated significant associations with obesity; rs1558902 was most significantly associated with obesity. P value in additive mode was 0.0000041, and odds ratio (OR) adjusted for age and gender was 1.41 [95% confidential interval (CI) = 1.22-1.62]. Obesity-associated phenotypes, which include the level of plasma glucose, hemoglobin A1c, total cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol, and blood pressure were not associated with the rs1558902 genotype. Thus, the SNPs in the FTO gene were found to be associated with obesity, i.e., severe obesity, in the Japanese.

引用

页码：546 / 553

页数：8

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