P(RNCH2CH2)N:: efficient catalysts for the cyanosilylation of aldehydes and ketones

被引：70

作者：

Fetterly, BM ^{[1
]}

Verkade, JG ^{[1
]}

机构：

[1] Iowa State Univ, Dept Chem, Ames, IA 50011 USA

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 46期

关键词：

proazaphosphatrane; aldehyde; ketone; trimethylsilylcyanide; cyanohydrin;

D O I：

10.1016/j.tetlet.2005.09.032

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The 1,2-addition of trialkylsilylcyanides to aldehydes and ketones produces the corresponding protected cyanohydrins in good to excellent yields when carried out at 0 degrees C to room temperature in the presence of catalytic amounts of the nonionic strong base P(RNCH2CH2)N (R = Me, i-Pr) in THF. These catalysts are easily removed from the product by hydrolysis or column filtration through silica gel. (c) 2005 Published by Elsevier Ltd.

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页码：8061 / 8066

页数：6

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