Enantioselective trimethylsilylcyanation of aromatic aldehydes catalyzed by titanium alkoxide-chiral o-hydroxyarylphosphine oxides complexes

被引：69

作者：

Brunel, JM ^{[1
]}

Legrand, O ^{[1
]}

Buono, G ^{[1
]}

机构：

[1] Fac Sci & Tech St Jerome, Ecole Natl Super Synth Proc & Ingn Chim Aix Marse, CNRS, UMR 6516, F-13397 Marseille 20, France

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 10期

关键词：

D O I：

10.1016/S0957-4166(99)00179-2

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A series of new chiral titanium alkoxide-o-hydroxyarylphosphine oxides complexes has been used as catalysts in the asymmetric trimethylsilylcyanation of aromatic aldehydes. The corresponding cyanohydrins have been obtained in high chemical yields with good to excellent enantiomeric excesses up to 98%. The influence of the structural features of the catalysts on the enantioselectivity has been investigated. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1979 / 1984

页数：6

共 35 条

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