Catalytic asymmetric synthesis of (S)-acetophenone cyanohydrin under high pressure

被引：42

作者：

Choi, MCK ^{[1
]}

Chan, SS ^{[1
]}

Matsumoto, K ^{[1
]}

机构：

[1] KYOTO UNIV,GRAD SCH HUMAN & ENVIRONM STUDIES,KYOTO 606,JAPAN

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 38期

关键词：

D O I：

10.1016/S0040-4039(97)01561-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first trimethylsilylcyanation of acetophenone to its (S)-cyanohydrin was accomplished with e.e. up to 60% in 93% yield at 0.8 GPa, using 0.01 eq. of a reuseable catalyst prepared from (S)-3,3-dimethyl-1,2,4-butanetriol and titanium isopropoxide.Reactions of 4'-substituted acetophenones to the corresponding cyanohydrins gave lower e.e. and yields. (C) 1997 Elsevier Science Ltd.

引用

页码：6669 / 6672

页数：4

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